Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PARKINSON'S DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PARKINSON'S DISEASE is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 2353 entities in the SciDEX knowledge graph.
| Gene Symbol | PARKINSON'S DISEASE |
| Associated Diseases | ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety |
| Known Drugs/Compounds | RAPAMYCIN, SEMAGLUTIDE, RESVERATROL, ADUCANUMAB, METFORMIN, LEVODOPA |
| Interactions | MICROGLIA, P62, ULK1, SQSTM1, NEUROINFLAMMATION, STAT1 |
| KG Connections | 4474 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| MICROGLIA["MICROGLIA"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| Inflammation["Inflammation"]
MITOPHAGY_2["MITOPHAGY"] -->|"activates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
end
subgraph Pathology["Pathology"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated with"| Parkinson["Parkinson"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated with"| Autophagy["Autophagy"]
PINK1["PINK1"] -->|"associated with"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
MITOPHAGY["MITOPHAGY"] -->|"associated with"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
ALS["ALS"] -->|"associated with"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
JUN["JUN"] -->|"associated with"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
end
subgraph Therapeutic["Therapeutic"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| Parkinson_1["Parkinson"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| Als["Als"]
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| Proteasome["Proteasome"]
end
style PARKINSON_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Parkinson_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOPHAGY fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOPHAGY_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Proteasome | therapeutic_target | pathway | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Parkinson | contributes_to | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| PARKIN | activates | gene | 1.00 |
| PINK1 | associated_with | gene | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| ALPHA-SYNUCLEIN | associated_with | gene | 1.00 |
| LRRK2 | associated_with | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| UBIQUITIN | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| ALPHA-SYNUCLEIN | therapeutic_target | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| Parkinson | protects_against | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PINK1 | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ALS | associated_with | gene | 1.00 |
| JUN | associated_with | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| NEURODEGENERATION | contributes_to | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| HUNTINGTON | associated_with | gene | 1.00 |
| PARKINSON | regulates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| PARKINSON | causes | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| PARKIN | associated_with | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| PARKINSON | therapeutic_target | gene | 1.00 |
| FERROPTOSIS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | regulates | gene | 1.00 |
| ASTROCYTES | associated_with | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| PARKINSON | treats | disease | 1.00 |
| NEURODEGENERATION | causes | disease | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| NEUROTOXICITY | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | treats | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| BDNF | associated_with | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| P62 | associated_with | protein | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| AMYLOID | associated_with | protein | 1.00 |
| MICROGLIA | associated_with | cell_type | 1.00 |
| AKT | associated_with | gene | 1.00 |
| LRRK2 | associated_with | gene | 1.00 |
| IL-6 | associated_with | gene | 1.00 |
| NF-KB | associated_with | protein | 1.00 |
| NRF2 | associated_with | gene | 1.00 |
| PARKINSON | biomarker_for | gene | 1.00 |
| AMPK | associated_with | gene | 0.96 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.95 |
| SNCA | associated_with | gene | 0.95 |
| ALZHEIMER'S DISEASE | processes | disease | 0.95 |
| DOPAMINERGIC NEURONS | depletes | cell_type | 0.95 |
| AGING | risk_factor_for | process | 0.95 |
| Cordycepin | protects_against | compound | 0.95 |
| Programmed Cell Death | involved_in | process | 0.95 |
| Cellular Senescence | causes | process | 0.95 |
| Inflammasome | contributes_to | pathway | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.467
neurodegeneration | 2026-04-01 | 0 hypotheses
neurodegeneration | 2026-04-01 | 0 hypotheses
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||